Interleukin 2-stimulated formation of ATP in T cell particles enriched with plasma membranes
Karelin, A.A.; Demidova, V.S.; Globa, A.G.; Marchuk, A.I.; Vtiurin, B.V.
Voprosy Meditsinskoi Khimii 35(3): 120-125
1989
ISSN/ISBN: 0042-8809 PMID: 2788959 Document Number: 342108
Distinct increase in content of ATP was found in preparations of enriched with plasmatic membranes particles from rat thymus T lymphocytes and from human peripheric blood T lymphocytes after their incubation with interleukin-2 as compared with controls which did not contain the peptide. The phenomenon observed was manifested only if these particles from T cells were preincubated with concanavalin A (2 min, 40 micrograms/ml), which is required to expression of the receptors for interleukin-2. The membrane-bound ATP, formed after the interleukin-2 effect on receptors of T lymphocytes, appears to serve as the secondary messenger activating protein kinase C.