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Effects of 3 doses of maprotiline (25, 50 and 75 mg) on alertness and memory in healthy volunteers

Warot, D.; Danjou, P.; Lacomblez, L.; Diquet, B.; Puech, A.J.

Therapie 44(4): 257-261

1989

ISSN/ISBN: 0040-5957
PMID: 2595643
Document Number: 341659
The effects on psychomotor and mnesic performance of acute oral doses of maprotiline (25, 50 and 75 mg) were evaluated in twelve healthy men in a placebo-controlled double blind study. A battery of tests was performed comprising: objective measures (critical flicker frequency, choice reaction time, memory tasks) and self rating evaluation (visual analogue scales). Tests session took place 15 hours after each treatment. Plasma concentrations of maprotiline were determined. Compared with placebo, maprotiline induced psychomotor impairment on both objective and subjective assessment in a dose related manner. No significant difference between maprotiline and placebo on memory test could be evidenced.

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