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Effect of 17-beta-estradiol on doxorubicin cytotoxicity in human breast cancer cell culture

Toma, S.; Leonessa, F.; Coialbu, T.; Nicolo, G.; Rosso, R.

Anticancer Research 9(2): 303-308

1989

ISSN/ISBN: 0250-7005
PMID: 2751257
Document Number: 341398
Pre-treatment with 17-beta-estradiol appeared to improve the cytotoxic efficacy of doxorubicin on MCF-7 but not on ZR-75-1 and EVSA-T human breast cancer cell lines. MCF-7 and ZR-75-1 are both estrogen receptor-positive cell lines: however, only ZR-75-1 showed improved proliferation in the presence of estradiol. On the other hand MCF-7 appeared basically more resistant to doxorubicin compared to the other cell lines. The results indicate that estrogenic pre-treatment is a potential tool for partially overcoming human breast cell resistance to doxorubicin; moreover, they suggest that the mechanism of interaction could be not exclusively related to actual cytokinetics modulation.

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