Evidence for a phosphatidylinositol anchor in glycolipid antigens of Leishmania major
Sevlever, D.; Londner, M.V.; Rosen, G.
Biochemistry International 19(1): 59-66
1989
ISSN/ISBN: 0158-5231 PMID: 2550007 Document Number: 341386
The structure of the membrane anchor of three Leishmania major surface antigenic glycolipids was analyzed. Phosphatidylinositol-specific phospholipase C treatment and nitrous acid deamination indicated the presence of a phosphatidylinositol anchor linked to the glycan through a non-N-acetylated hexosamine. An ester linkage on the C-2 of glycerol was revealed by phospholipase A2 hydrolysis. This fatty acyl substitution was not found on the phosphatidylinositol anchor of the Leishmania lipophosphoglycan.
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