Remarkable pain relief in the treatment with high-dose medroxyprogesterone acetate in advanced prostatic carcinoma
Sasagawa, I.; Satomi, S.; Katayama, T.
Gan no Rinsho. Japan Journal of Cancer Clinics 35(6): 767-771
1989
ISSN/ISBN: 0021-4949 PMID: 2470932 Document Number: 340737
A 60-year-old man was admitted to our hospital because of lumbago due to a metastatic bone tumor that originated from the prostate. Previously, he had been treated with 500 mg/kg of diethylstilbestrol diphosphate and 75 mg/day of chlormadinone acetate. At our hospital, he was given 470.1 mg/day of estramustine sodium phosphate and a bilateral orchiectomy was performed. However, he felt increased lumbago. Thus, a dose of 1200 mg/day of medroxyprogesterone acetate was started. Although the histology of his prostate and bone scintigram did not change, the patient no longer felt lumbago from about 2 weeks after the start of this treatment. Six months later, he remains free of lumbago. In this report, we describe the effect of high-dose medroxyprogesterone acetate on the clinical course, and the plasma and urine levels of the hormones.