Continuous flow peritoneal dialysis in pigs, using a silicone rubber double lumen catheter
Geary, D.F.; McLorie, G.A.; Bahoric, A.; Sakai, H.; Albisser, A.M.; Balfe, J.W.
International Journal of Artificial Organs 12(7): 428-432
1989
ISSN/ISBN: 0391-3988 PMID: 2767787 Document Number: 340733
Continuous flow (CFPD) and intermittent (IPD) peritoneal dialysis were compared in pigs, using a double lumen silicone rubber peritoneal dialysis catheter. For CFPD, after instillation of 30 ml/kg into the peritoneal cavity, dialysate was continually infused and drained at approximately 25 ml/kg/h. A dwell volume of 30 ml/kg was also used for IPD. Similar length cycles of each technique were compared in Experiment 1. In Experiment 2 total solute clearance and ultrafiltration achieved over two consecutive IPD cycles were compared with CFPD of a similar duration. The catheter functioned well with few complications. In Experiment 1, CFPD produced greater ultrafiltration and significantly improved the clearance of urea, potassium and phosphate compared to IPD. No significant difference between the techniques was observed in Experiment 2. Our data suggest that for CFPD to retain its advantage over IPD intermittent complete drainage of the peritoneal cavity may be necessary.