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Prolongation of heart allograft survival in course of donor specific antigen and alloserum treatment in the rat

Romaniuk, A.; Ryffa, T.; Rowiński, W.; Olszewski, W.L.

Archivum Immunologiae et Therapiae Experimentalis 37(3-4): 253-260

1989

ISSN/ISBN: 0004-069X
PMID: 2639625
Document Number: 340049
Different cell subpopulations involved in the induction of immune enhancement of the heart graft survival in rats differing across the major histocompatibility barrier has been studied. Cells devoid of class II antigens on their surface, e.g. erythrocytes, platelets, and thymocytes have been found ineffective, whereas subpopulations rich in class II antigens were found to be highly effective in induction of specific unresponsiveness when combined with donor specific alloserum. Our results suggest that class II antigens take part not only in induction of rejection response but may be also responsible for generation of specific unresponsiveness towards donor antigens.

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