Indoleamine 2,3-dioxygenase--a new antioxidant enzyme
Sun, Y.
Materia Medica Polona. Polish Journal of Medicine and Pharmacy 21(3): 244-250
1989
ISSN/ISBN: 0025-5246 PMID: 2491278 Document Number: 339757
Indoleamine 2,3-dioxygenase (IDO) was first found in rabbit intestine by Hayaishi et al. in 1963. The enzyme has a broad substrate specificity for various indoleamine derivatives and utilizes the superoxide anion as an oxygen source. IDO catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules including tryptophan, tryptamine, serotonin and melatonin, and produces a new type of biogenic amine that may be termed an anthraniloylalkylamine, as shown in Fig. 1.