Mechanism of changes in amine binding to plasma proteins during allergy
Shleĭkin, A.G.; Gor'kova, L.B.; Pozhilenkova, K.S.; Zvezdochkin, A.G.
Voprosy Meditsinskoi Khimii 35(2): 86-89
1989
ISSN/ISBN: 0042-8809 PMID: 2741420 Document Number: 339512
Blood plasma of healthy persons bound 13.13 +/- 1.07 mmol/l of p-phenylene diamine (PDA), histamine pectic index constituted 33.3 +/- 2.18%. In patients with neurodermitis and eczema both these patterns were markedly reduced. Unitiol (10(-3) mol/l) increased PDA binding and histamine level in vitro. The same concentration of cystamine decreased histamine pectic index in healthy persons. Importance of protein SH-groups in binding of amines is discussed.