Staphylococcal antigens cross-reacting with mammalian tissues and their role in inducing immunopathological processes
Romanov, V.A.; Khanna, A.T.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 5: 77-80
1989
ISSN/ISBN: 0372-9311 PMID: 2675502 Document Number: 338176
In the reaction of cross adsorption of immune sera to white mouse skin and staphylococcus with the corresponding antigens, the presence of an antigen related to white mouse skin and kidney antigens has been established in Staphylococcus aureus strain Wood-46 (not producing protein A) by means of the complement fixation test and the passive hemagglutination test. The capacity of staphylococcal antibodies and their fluorochrome-labeled fragments to specifically stain the cells of the epidermis and the renal tubules of mammals has been demonstrated. Staphylococcus epidermidis has proved to be unrelated to mammalian tissues. The significance of the data obtained in this investigation for the practice of the transplantation of organs and tissues, for more accurate determination of the pathogenesis of staphylococcal infections and for the development of immunologically safe vaccines in discussed.