Nifedipine reversal of decreased serotonin metabolite levels during morphine withdrawal
Colado, M.I.; Lorenzo, P.; Martín, M.I.
Archives Internationales de Pharmacodynamie et de Therapie 298: 61-67
1989
ISSN/ISBN: 0003-9780 PMID: 2474270 Document Number: 338079
Morphine withdrawal induced by naloxone produced a significant decrease in serotonin turnover of guinea-pig brain. Nifedipine pretreatment markedly prevented this change induced by the abstinence syndrome. These data provide further evidence that nifedipine is effective in blocking the neurochemical expression of morphine abstinence.
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