Plasmapheresis in the treatment of peripheral HIV neuropathy
Salim, Y.S.; Faber, V.; Skinhøj, P.; Lerche, B.; Søeberg, B.; Mikkelsen, S.; Klinken, L.; Trojaborg, W.; Jakobsen, J.; Kamieniecka, Z.
Ugeskrift for Laeger 151(27): 1754-1756
1989
ISSN/ISBN: 0041-5782 PMID: 2551089 Document Number: 338041
Peripheral neuropathy following HIV infection is frequently seen among HIV-positive-, ARC- and AIDS patients who often complain of debilitiating paresthesias. Indirect immunofluorescence technique showed antibodies directed either to myelin and/or axons and to endothelial cells of the blood vessels within the nerve tissue. Sural nerve biopsies from five patients showed demyelination, axonal degeneration and perivascular cellular infiltration. Two of the patients had nuclear inclusions and high anti-CMV titer. Plasma exchange was undertaken on five HIV infected patients which resulted in complete disappearance of symptoms in three, incomplete remission in one and no effect in one patient. The finding of autoantibodies against different nerve tissue components, cellular infiltration, positive effect of the plasma exchange and relapse suggests that autoimmunity may play a pathogenetic role in some of the HIV infected patients with peripheral neuropathy.