Histopathology and immunohistopathology of lymph nodes of the first autopsy with HIV positivity in China
Lai, M.D.; Xu, Y.H.; Dai, D.; Tang, D.J.; Han, Y.J.
Chinese Medical Journal 105(10): 813-817
1992
ISSN/ISBN: 0366-6999 PMID: 1337874 Document Number: 337473
Nineteen lymph nodes of a HIV-positive boy were studied histologically and immunohistologically. According to Stutte's classification of HIV-related lymphadenopathy, 84% of the lymph nodes were at the third or fourth stages in relation to clinical status ARC/AIDS. Lymph follicle atrophy, angiogenesis, histiocytic proliferation and destruction of the normal reticulum frame were observed. Immunohistochemical studies showed most of the remaining lymphocytes to be T cells and changes in the distribution of S-100 positive cells. Ki 1 positive cells existed mainly at the second stage. The significance of these changes is discussed.