Moderate deficiency of Factor XIi associated with postoperative deep venous thrombosis
Cornudella, R.; Puente, F.; Hortells, J.L.; Gutiérrez, M.
Sangre 34(2): 144-146
1989
ISSN/ISBN: 0036-4355 PMID: 2756451 Document Number: 337234
The interrelationship between factor XII deficiency (Hageman trait) and thrombosis is well known. A case of moderate factor XII deficiency (activity, 30%) associated to deep vein thrombosis, which occurred in the popliteal region of the left lower limb after abdominal surgery, is reported. The deficit was found in 4 family members of the three generations studied, and all of them showed a close interrelationship between factor XII activity and kallikrein levels. Prolonged APTT was found in 3 of the 4 affected subjects. A multiallelic model is suggested to explain the genetic transmission of this impairment.