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The chemical modification of immunoglobulins for accelerating their elimination from the blood flow during radioimmunodiagnosis

Mukhamedova, N.M.; Obukhov, S.K.; Slinkin, M.A.; Klibanov, A.L.; Torchilin, V.P.

Biulleten' Eksperimental'noi Biologii i Meditsiny 108(12): 705-707

1989

ISSN/ISBN: 0365-9615
PMID: 2634444
Document Number: 337165
Immunoglobulins were modified by diethylenetriaminepentaacetic acid anhydride and sulfosuccinimidy 16-(biotinamido) hexanoate and were conjugated with modified polylysine. Biodistribution of the samples was observed before and after avidin injection. Samples containing no polylysine accumulate in reticuloendothelial system, protein conjugate with polylysine concentrate in kidneys. The results demonstrate that drug distribution depends on the type of modification.

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