The potentials for immunization against influenza using liposome-incorporated viral surface antigens
Burducea, O.; Marcheş, F.; Duţu, C.; Grancea, C.; Nicolau, A.; Păun, C.
Virologie 40(2): 97-106
1989
ISSN/ISBN: 0253-181X PMID: 2781727 Document Number: 336683
Studies were conducted using uni- and multilamellar liposomes to establish optimum conditions for influenza antigen incorporation in view of their transport to the target cells for experimental influenza prophylaxis in hybrid white mice. Radiometric determinations showed a good level of preparation purification, a good efficiency of incorporation in liposomes of the active biological material, the liposome linked radioactivity distribution among different organs. Charged liposomes induced solid and long lasting resistance against influenza control infection.