Treatment of vaso-occlusive crisis of sickle-cell disease with pentoxifylline
Clerc, M.; Doh-Egueli, D.; Chapuis, F.; Durin, A.; Bertrand, Y.; Souillet, G.; Philippe, N.
Pediatrie 44(7): 577-581
1989
ISSN/ISBN: 0031-4021 PMID: 2812975 Document Number: 336658
Sickle-cell disease is usually complicated by vaso-occlusive attacks. A review of the case-histories of 26 patients permitted an analysis of 92 severe attacks. We compared the outcome of 52 attacks treated with hyperhydration associated with a modifying erythrocyte membrane agent (pentoxifylline), with 40 attacks treated with hyperhydration and other drugs. This result compares well the current knowledge of the rheologic mechanisms involved in vaso-occlusive attacks of sickle-cell disease.