Very high dose intravenous gammaglobulin in thrombocytopenia of pregnancy
Gibson, J.; Laird, P.P.; Joshua, D.E.; Child, A.; Harris, J.; Kronenberg, H.
Australian and New Zealand Journal of Medicine 19(2): 151-153
1989
ISSN/ISBN: 0004-8291 PMID: 2764818 Document Number: 335806
A 22-year-old woman with severe idiopathic thrombocytopenic purpura, complicating pregnancy, was unresponsive to high-dose corticosteroids and three separate infusions of high-dose intravenous immunoglobulin using the conventional schedule of 400 mg/kg/d for five days. A dramatic albeit transient, elevation of her platelet count followed a six day course of very high dose immunoglobulin (1000 mg/kg/d) thus allowing elective lower segment cesarean section to be performed without complications and with the delivery of a live, female infant. Two months later a further course of very high dose gammaglobulin was again effective in raising the patient's platelet count prior to elective splenectomy. No adverse reactions were seen to either infusion.