Retinal cotton-wool-like spots: a marker for AIDS?
Pezzi, P.P.; Tamburi, S.; D'offizi, G.P.; Mezzaroma, I.; Aiuti, F.
Annals of Ophthalmology 21(1): 31-33
1989
ISSN/ISBN: 0003-4886 PMID: 2930117 Document Number: 335695
The prognostic value of ocular manifestations and its correlation with immune changes in HIV-infected subjects was studied longitudinally with an average follow-up of one year (3-22 months). The most common ocular manifestations were retinal cotton-wool-like spots, observed in 58.8% of AIDS patients and in 76.9% of those with ocular involvement. Two of three ARC cases with cotton-wool-like spots developed Pneumocystis carinii pneumonia a few weeks after ophthalmoscopic examination. A close correlation between ocular changes and decrease of CD4+ lymphocytes was observed. In our opinion, these ocular manifestations are as useful as opportunistic infections or AIDS-related neoplasias in the natural history of HIV infection.