Methodologic principles for the prognosis of chronic toxicity of substances based on results of short-term trials
Sidorenko, G.N.; Zoldakova, Z.I.; Krasovskij, G.N.
Zeitschrift für die Gesamte Hygiene und ihre Grenzgebiete 35(3): 133-136
1989
ISSN/ISBN: 0049-8610 PMID: 2658380 Document Number: 335295
One of the most important concerns of air-hygienic research is the determination of the threshold concentration for the influence of air-contaminating substances. The threshold concentrations are the basis of the air-hygienic norms. The experimental determination of the threshold concentration with chronical influence is expensive and needs a lot of time. A new method of extrapolation of the toxicity values obtained from subacute experiments is described. Different from other methods of extrapolation the biological qualities of the substances as well as the peculiarities of the toxic process are taken into consideration. In addition, evidence on the optimal duration of the chronical experiment can be derived. The extrapolation method described is not applicable to substances with extremely intensive cumulation.