DNA diagnostics in hemophilia a and B
Alkan, M.; Malik, N.J.; Borer, U.V.; Müller, H.; Bühler, E.M.
Schweizerische Medizinische Wochenschrift 119(38): 1296-1302
1989
ISSN/ISBN: 0036-7672 PMID: 2587968 Document Number: 335176
Carrier detection and prenatal diagnosis of hemophilia A and B are possible with cloned factor-VIII:C- and factor-IX-gene-specific or linked probes which detect restriction fragment length polymorphisms (RFLPs). In this study, 12 hemophilia-A- and 5 hemophilia-B-families were studied to identify carriers and provide adequate genetic counselling to women who were heterozygous for one or more of the intragenic or linked DNA probes with respect to future pregnancies.