Reduced schedule of human antirabies immunization with Fuenzalida & Palacios vaccine
Zanetti, C.R.; Favoretto, S.R.; Tino, M.S.; Albas, A.; Valentini, E.J.; Pereira, O.A.
Revista do Instituto de Medicina Tropical de Sao Paulo 31(1): 23-27
1989
ISSN/ISBN: 0036-4665 PMID: 2814201 Document Number: 335090
The present study evaluates the humoral and cellular immune responses in 35 volunteers submitted to short antirabies vaccination schedules with the Fuenzalida and Palacios vaccine based on the administration of doses on non consecutive days. The volunteers were divided into two groups. The first group received a total number of five doses given on days 0, 4, 7, 20 adn 35. The other group received four doses, the first one being a double dose given on day 0 and than three other single doses on days 7, 20 and 35. The evaluation of humoral immune response was carried out by serum neutralization (SN) and indirect immunofluorescense (IIF) test, while the cellular immune response was evaluated by lymphoblastic transformation assay (LTA) and skin test (ST). According to our results these reduced shedules elicited early and effective humoral and cellular immune responses to rabies antigen suggesting that new reduced schedules should be extensively studied in order to give the proper bases to the proposition of changes in the current long-term schedule.