Neurologic findings in men with isolated hypogonadotropic hypogonadism
Schwankhaus, J.D.; Currie, J.; Jaffe, M.J.; Rose, S.R.; Sherins, R.J.
Neurology 39(2 Pt 1): 223-226
1989
ISSN/ISBN: 0028-3878 PMID: 2915793 Document Number: 334878
We studied the neurologic abnormaliteis in 41 men with isolated hypogonadotropic hypogonadism. Findings included anosmia, hyposmia, mirror movements, ocular motor abnormalities, cerebellar dysfunction, and pes cavus foot deformity. One-third of the subjects had a family history of delayed sexual maturation. Patients with a family history of delayed sexual maturation had a significantly higher incidence of olfactory dysfunction, mirror movements, and pes cavus foot deformity. Our data suggest that isolated hypogonadotropic hypogonadism and its accompanying neurologic abnormalities may arise from a genetically linked developmental abnormality of CNS structures.