Various doses cisplatin combined with multi-drug chemotherapy of malignant solid tumors
Wang, Q.L.
Zhonghua Zhong Liu Za Zhi 11(3): 222-225
1989
ISSN/ISBN: 0253-3766 PMID: 2612337 Document Number: 334783
236 patients with various advanced malignant solid tumors treated by comined chemotherapy with routine doses of cisplatin (DDP) from 1980 to 1086 are presented. According to different doses of cisplatin every day, the patients were divided into 4 groups: 1. 20 mg/day .times.4.apprx.5, 80 cases; 2. 30 mg/day .times. 3.apprx.5, 91 cases; 3. 40 mg/day .times. 3.apprx.4, 37 cases; 4. 50 mg/day .times.2.apprx.3, 28 cases. Each group was repeated for 3 weeks. The effect and toxicity were analysed and compared with 22 cases treated by single DDP in 1975. The response (CR+PR) rate was 39.2% in 194 evaluated patients. The response rate was simialr in group 20 mg and single DDP (29.2% and 27.3%). The response rate waslower than that of group 30 mg, 40 mg, and 50 mg (43.4%, 42.4%, and 50%) (P<0.05). The remissions in various groups were not significantly different. The toxicity of combined chemotherapy was not severe. 91.1% of patients had nausea and vomiting. There was no statistical difference in the various groups. Bone marrow suppression was less in single DDP group than that of combined chemotherapy group, (P<0.05). DDP 30 mg.apprx.50 mg 1/d .times. 5.apprx.3 was better than HD-DDP in some patients.