The impact of purposeful sharing by HLA matching in the South Eastern Organ Procurement Foundation (SEOPF)
Pfaff, W.W.; Sanfilippo, F.; Lucas, B.A.; Vaughn, W.K.
Transplantation Proceedings 21(1 Part 2): 1405-1407
1989
ISSN/ISBN: 0041-1345 PMID: 2652453 Document Number: 334752
A voluntary system was created to foster early sharing of well-matched organs between like-minded renal transplantation programs. In the two historic periods 1982-85 and 1985-86, sharing programs (Category I & II) and nonsharing programs (Category III) had similar graft survival. In the study period 1986-88, graft survival improved in Category I and II programs and was unchanged in Category III programs. Highly sensitized recipients in sharing programs had an incremental gain of 15.0%, patients receiving multiple grafts 12.6%. Grafts derived from local donors and transplants in less sensitized patients also were improved but for less obvious reasons. The implementation of this study was followed by a slight decrement in delayed graft function. It is our conclusion that early graft sharing can result in improved overall early graft survival.