Interaction of nimodipine and isoflurane in surgery of intracranial aneurysm
Adnet, P.; Fesard, P.; Riegel, B.; Debout, J.; Krivosic-Horber, R.
Agressologie Revue Internationale de Physio-Biologie et de Pharmacologie Appliquees Aux Effets de l'Agression 30(7): 399-401
1989
ISSN/ISBN: 0002-1148 PMID: 2817234 Document Number: 334154
A moderate controlled hypotension has been performed with isoflurane in the presence of nimodipine (4 mg.h-1) on ten patients anesthetized for cerebral aneurysm clipping. The administration of both drugs induced a dose-dependent hypotension secondary to the reduction of the systemic vascular resistance without impairment of cardiac index. Nimodipine did not modify the cardiovascular effects of isoflurane. It is concluded that intravenous administration of nimodipine should be continued during the operative period.