The relationship between the prostaglandin e level in the tumor and the times of the metastasis of primary osteogenic sarcoma
Bassalyk, L.S.; Kushlinskiĭ, N.E.; Solov'ev, I.N.; Siniukov, P.A.; Fedenko, A.N.
Voprosy Onkologii 35(11): 1301-1305
1989
ISSN/ISBN: 0507-3758 PMID: 2609517 Document Number: 334137
Radioimmunoassay was used in 46 cases of osteogenic sarcoma to assess prostaglandin E (PgE) levels in tumor tissue. Those levels were found to vary with age. A correlation was established between the effect of preoperative chemoradiation treatment, on the one hand, and degree of treatment-induced pathomorphosis and PgE concentration in tumor, on the other. High PgE level in osteogenic sarcoma tissue proved prognostically unfavorable whatever age and prior chemoradiation treatment and were associated with shorter metastasis-free survival.