A randomized comparison of ginger and dimenhydrinate in the treatment of nausea and vomiting in pregnancy
Pongrojpaw, D.; Somprasit, C.; Chanthasenanont, A.
Journal of the Medical Association of Thailand 90(9): 1703-1709
2007
ISSN/ISBN: 0125-2208 PMID: 17957907 Document Number: 3338
To study the efficacy of ginger and dimenhydrinate in the treatment of nausea and vomiting in pregnancy. Double blind randomized controlled trial. Department of Obstetrics and Gynecology, Thammasat Hospital, Faculty of Medicine, Thammasat University. Between January 2005 and December 2005, 170 pregnant women who attended at antenatal clinic Thammasat University Hospital with the symptoms of nausea and vomiting in pregnancy were randomly allocated into group A (n = 85) and group B (n = 85). The patients in group A received one capsule of ginger twice daily (one capsule contained 0.5 gm of ginger powder) while the patients in group B received the identical capsule of 50 mg dimenhydrinate twice daily. The visual analogue nausea scores (VANS) and vomiting times were evaluated at day 0-7 of the treatment. There was no significant difference in the visual analogue nausea scores (VANS) between group A and group B in day 1-7 of the treatment. The vomiting episodes of group A were greater than group B during the first and second day of the treatment with statistically significant difference. No difference in vomiting episodes during the day 3-7 of treatment was found in both groups. There was a statistically significant difference in the side effect of drowsiness after treatment in group B greater (77.64%) than group A (5.88%) (p < 0.01). From the presented data, ginger is as effective as dimenhydrinate in the treatment of nausea and vomiting during pregnancy and has fewer side effects.
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