Adult enuresis. The role of vasopressin and atrial natriuretic peptide
Rittig, S.; Knudsen, U.B.; Jønler, M.; Nørgaard, J.P.; Pedersen, E.B.; Djurhuus, J.C.
Scandinavian Journal of Urology and Nephrology. Supplementum 125: 79-86
1989
ISSN/ISBN: 0300-8886 PMID: 2534442 Document Number: 333747
In 8 adult patients with monosymptomatic nocturnal enuresis (age 18-44 years) we twice investigated the circadian rhythm of plasma vasopressin, plasma atrial natriuretic peptide, serum osmolality, serum electrolytes as well as urinary excretion in relation to urodynamic variables. Seven of the patients showed a lack of diurnal rhythmicity in plasma vasopressin at both diurnal studies with no night-time increase. The nocturnal urinary volumes exceeded the bladder capacities with an average of 155%. This was mainly caused by a large excretion of poorly concentrated urine during the first hours of sleep. Although a slight nocturnal peak in plasma atrial natriuretic peptide was found no clear pathophysiological role could be determined for this peptide. It is concluded that the previously established vasopressin production abnormality in juvenile enuresis seems to persist in adult enuretics.