Effects of cerebral GABA level on learning and memory
Zhang, S.S.; Zhu, T.J.; Zhang, D.S.; Chen, X.Y.
Zhongguo Yao Li Xue Bao 10(1): 10-12
1989
ISSN/ISBN: 0253-9756 PMID: 2816394 Document Number: 333005
In step-down tests, icv GABA 0.1 micrograms (3 min before training) or ip amino-oxyacetic acid 20 mg/kg (1.5 h before training) both significantly impaired memory acquisition in mice. But semicarbazide (ip 110 mg/kg 3.5 h before training), an inhibitor of GABA synthesis, improved the anisodine-induced impairments of learning. The effects of GABA was also enhanced by aminooxyacetic acid. The results suggest that the increase of cerebral GABA contents is unfavourable to learning and memory.