The effect of clomiphene citrate on follicular phase increase in endometrial thickness and uterine volume
Eden, J.A.; Place, J.; Carter, G.D.; Jones, J.; Alaghband-Zadeh, J.; Pawson, M.E.
Obstetrics and Gynecology 73(2): 187-190
1989
ISSN/ISBN: 0029-7844 PMID: 2492092 Document Number: 332498
Fifteen ovulating women had serial ultrasound scans to measure follicular, endometrial, and uterine growth, as well as biochemical indices including estradiol (E2) and the free androgen index, throughout a natural and a clomiphene-citrate-induced cycle. Despite higher E2 levels in the 5 days preceding ovulation, the clomiphene cycles were characterized by absence of the normal increase in uterine volume and an inhibition of endometrial thickening. It is proposed that the anti-estrogen effect of clomiphene inhibits the normal cyclical growth of the uterus and endometrium.