Effects of intravenous administration of bupivacaine on the renal sympathetic nerve activity in the cat
Fukuda, T.
Masui. Japanese Journal of Anesthesiology 38(12): 1554-1560
1989
ISSN/ISBN: 0021-4892 PMID: 2614882 Document Number: 330878
The effects of an i.v. bolus injection of sub-seizure doses of bupivacaine on the renal sympathetic nerve activity (RSNA), mean arterial pressure (MAP) and heart rate (HR) were studied in cats. The cats received intravenous administration of bupivacaine (0.4 mg .cntdot. kg-1, 0.8 mg .cntdot. kg-1 and 1.2 mg .cntdot. kg-1 at 50- and 110-min interval respectively in order of increasing doses) during nitrous oxide anesthesia and nitrous oxide-halothane anesthesia. During nitrous oxide anesthesia, MAP and HR did not change significantly with all doses of bupivacaine. RSNA increased at first and then decreased slightly following all doses of bupivacaine. In cats with denervated baroreceptor, a change of RSNA after bupivacaine 0.8 mg .cntdot. kg-1 i.v. was similar to that in intact cats. In contrast, RSNA, MAP and HR decreased significantly following bupivacaine 1.2 mg .cntdot. kg-1 i.v. during nitrous oxide-halothane anesthesia. Cardiovascular depression following bupivacaine i.v. during nitrous oxide-halothane anesthesia may be caused by both a decreased sympathetic activity and a direct myocardial depression.