Beta-hCG vs intact hCG assays in the detection of trophoblastic disease
Rinker, A.D.; Tietz, N.W.
Clinical Chemistry 35(8): 1799-1800
1989
ISSN/ISBN: 0009-9147 PMID: 2474392 Document Number: 330762
We describe a case of choriocarcinoma in which increased concentrations of beta-choriogonadotropin subunits in serum indicated recurrence of metastasis long before the tumor could be confirmed by visualization techniques, while intact choriogonadotropin remained normal (less than 5 int. units/L). Therefore, detection or monitoring of choriocarcinoma requires the assay of free beta-hCG subunit or an assay that measures both the free beta-subunit and intact choriogonadotropin.
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