The detection of antigenemia in typhoid patients at different periods in the course of the infection
Gorelov, A.L.; Levina, G.A.; Prozorovskiĭ, S.V.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 12: 33-36
1989
ISSN/ISBN: 0372-9311 PMID: 2483481 Document Number: 330754
The enzyme immunoassay of serum samples, obtained from 37 typhoid patients and previously subjected to bacteriological study with negative results, permitted the detection of S. typhi specific antigens and, as a consequence, the rapid diagnosis of the disease. The prevalence of various antigenic components of S. typhi was observed at different stages of infection. The presence of surface O and Vi antigens was characteristic of acute stages of S. typhi infection. At the same time L-form antigens, in rare cases in combination with surface O and Vi antigens, were characteristic of patients at the period following the acute stage of the disease, as well as chronic carriers. This is indicative of the necessity of introducing specific antibodies to the antigenic determinants of S. typhi L forms into the assortment of diagnostic immune preparations.