Effects of acute amphetamine treatment on the butyrylcholinesterase activity in adrenal glands of mice
Bhatnagar, M.; Pandey, V.N.; Tewari, H.B.
Archives Internationales de Pharmacodynamie et de Therapie 302: 68-73
1989
ISSN/ISBN: 0003-9780 PMID: 2636826 Document Number: 330515
Butyrylcholinesterase (BChE, EC 3.1.1.8.) activity in adrenal cortex and medulla was studied in control mice and in mice treated with DL-amphetamine. Amphetamine 6 mg/kg body weight, enhanced the enzyme activity in the adrenal medulla. In cortical layers, the effect was different for various layers; the enzyme activity decreased in the zona glomerulosa and in the zona reticularis, but remained unaltered in the zona fasciculata. In view of various neuronal and nonneuronal functions of BChE, it is suggested that the difference in effect of amphetamine on activity of BChE in various parts of glands is due to the neuronal and nonneuronal origin and function of the adrenal medulla and the cortex.