Hormone-releasing silicone-rubber intrauterine contraceptive devices. Effect of incorporation of various compounds on intrauterine contraceptive devices in rats
Doyle, L.L.
American Journal of Obstetrics and Gynecology 121(3): 405-411
1975
ISSN/ISBN: 0002-9378 PMID: 1115155 DOI: 10.1016/0002-9378(75)90021-6Document Number: 330378
The effect that incorporation of 8 different compounds into IUDs has on retention and reproduction in rats was studied. IUDs containing 0, 5, or 10% by weight of progesterone, melengestrol acetate (MGA), norethindrone, norgestrel, medroxyprogesterone acetate, isoxsuprine, R2323, or wound copper wire were placed in 1 or both horns. The animals were checked daily to be sure all were exhibiting normal estrous cycles and those used in mating studies were checked daily for presence of a plug or sperm which was designated Day 1 of pregnancy. The retention rate of those with progestins at 2 weeks ranged from 80 to 100% compared to 17.4% retention in controls. Progesterone and isoxsuprine had little effect and copper had no effect. Local or systemic effects on estrous cycle, mating, ovulation, fertilization, tubal transport, and implantation varied among the compounds and dosages. 5% MGA decreased uterine motility. Consistent results could not be obtained with the other compounds.