Mechanism of phasic fluctuations of glycemia after administration of diabetogenic substances
Gold'berg, E.D.; Eshchenko, V.A.
Problemy Endokrinologii 35(3): 78-80
1989
ISSN/ISBN: 0375-9660 PMID: 2762269 Document Number: 330246
Dithizone induces similar glycemic changes in rabbits, golden hamsters and mice (triphasic fluctuations resulting in diabetes). In rabbits who received 8-(p-toluenesulfonylamino)-quinoline, 8-(benzenesulfonylamino)-quinoline or alloxan, the glycemic reaction is similar to that observed after a dithizone injection. A degree of glycemic reaction to chromophiric chelants injected to animals, depends on their accumulation in the lysosome-segregation apparatus, of insulin producing cells (acidotropic action).