New possibilities in the hormonal therapy of metastatic carcinoma of the prostate
Cicin-Sain, D.; Pasini, J.
Lijecnicki Vjesnik 111(11): 405-407
1989
ISSN/ISBN: 0024-3477 PMID: 2699907 Document Number: 330243
The application of estrogens in cases of prostatic cancer was widely accepted due to the discovery that they decreased the serum testosterone level. Yet, it was soon evident that their application did not always lead to the expected therapeutic effect, and thus the scientists kept on searching for the substances which would overcome the drawbacks of estrogen therapy. The paper describes the mechanisms of the activity of the three new groups of drugs which could be taken as the alternative to the estrogen therapy or castration in cases of advanced prostatic cancer.