Clinical evaluation of a 1 protocol in advanced neuroblastoma
Iwafuchi, M.; Ohsawa, Y.; Hirota, M.; Matsuda, Y.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 16(4 Pt 2-2): 1323-1328
1989
ISSN/ISBN: 0385-0684 PMID: 2730045 Document Number: 329713
For the purpose of studying clinical evaluation of A 1 protocol for advanced neuroblastoma, chemotherapy with vincristine, cyclophosphamide, THP-adriamycin and cisplatin was performed in 8 pediatric patients with advanced neuroblastoma undergoing second look operation (4) or delayed primary operation (4). Tumor volume measured on CT, histological finding of tumor obtained at operation, blood and urinary tumor marker level were studied. 1) The chemotherapy is supposed to be effective for round cell type neuroblastoma. On the other hand, it is ineffective for composite type ganglioneuroblastoma. 2) More than 3 courses of A 1 protocol are necessary to yield a good effect. 3) There is no relationship between the effect of the chemotherapy and the prognosis.