Chronic granulomatous disease of childhood. Report of two cases with unusual involvement of the gastric antrum and spleen
Orduña, M.; González de Orbe, G.; Gordillo, M.I.; Fernández-Epifanio, J.L.; Serrano, C.; Collado, J.M.; Miralles, M.
European Journal of Radiology 9(1): 67-70
1989
ISSN/ISBN: 0720-048X PMID: 2659361 Document Number: 329550
Chronic granulomatous disease (CGD) of childhood is a rare entity. The disease is characterized by recurrent infections with granuloma and abscess formation caused by an inherited defective neutrophil leukocyte function. The most common sites of involvement are the lungs, lymph nodes, skin, liver, spleen and bones. Rarely are other organs affected. Two children with CGD are presented. The children were cousins, the older with bone, lung and splenic involvement. The younger had circumferential thickening of the gastric antrum. Some of the lesions were well delineated with ultrasonography. The unusual gastric antrum wall and focal splenic involvement in this disease are emphasized.