Post-traumatic edema as a limiting factor in early functional treatment measures and its pharmacodynamic modification
Nissen, R.; Loeschke, S.; Peters, A.
Langenbecks Archiv für Chirurgie. Suppl Ii Verhandlungen der Deutschen Gesellschaft für Chirurgie. Deutsche Gesellschaft für Chirurgie. Kongress 1989: 475-478
1989
ISSN/ISBN: 0173-0541 PMID: 2485152 Document Number: 329408
Post-traumatic oedema is a limiting factor of early functional exercise following fractures. A review of drug prophylaxis used in many clinical studies is given. A 30% reduction of oedema development following bimalleolar fractures was achieved with cyclooxigenase inhibitors (azapropazone) and aprotinin. It is pointed out that non-steroidal antiphlogistic drugs inhibit the collagen metabolism during the healing of rat skin-wounds.