Current trends in experimental peripheral nerve regeneration
Lejeune, G.; Foidart, M.; Severyns, A.M.; Delree, P.; Lejeune, A.; Clermont, D.; Rocoux, G.
Bulletin et Memoires de l'Academie Royale de Medecine de Belgique 144(10): 469-75; discussion 476-7
1989
ISSN/ISBN: 0377-8231 PMID: 2629960 Document Number: 329253
Large posttraumatic defects in the peripheral nervous system need to discover methods to solve the demand of nerve grafts. There is no definite answer now. The authors present a model for nervous regeneration studies. Experiments are performed in the Wistar rat. A venous isograft is used to bridge defects of various size in a divided rat sciatic nerve. The venous tube is a guide for axonal regeneration. In one series, the tube is filled with physiological saline and, in a second one, neonatal Schwann cells are injected in the venous isograft. Results recorded are a combination of quantitative methods: neurophysiology and morphometry. The injection of neonatal Schwann cells is able to stimulate nerve regeneration but not completely.