Method for evaluating the reinforcing properties of morphine in a model of addictive behavior
Surkova, L.A.; Tiurina, I.V.
Farmakologiia i Toksikologiia 52(4): 93-95
1989
ISSN/ISBN: 0014-8318 PMID: 2806539 Document Number: 328344
An animal model of addiction is described. The albino rats learned to come into the right arm of the Y-type maze where they received intraperitoneal injections of morphine in a dose of 5 mg/kg or distilled water (control group). It was found that morphine-dependent rats much more frequently visited the right arm. Thus it is possible to estimate quantitatively the positive reinforcing effect of morphine.