A suppressive mechanism counteracts the production of anti-idiotype antibody
Korec, E.; Korcová, J.; Hlozánek, I.
Folia Biologica 35(5): 347-350
1989
ISSN/ISBN: 0015-5500 PMID: 2699293 Document Number: 328258
BALB/c mice were repeatedly, at two-week intervals, immunized with monoclonal antibody against hepatitis B surface antigen and their sera were titrated for anti-idiotype antibody. The highest titres appeared after 1-4 immunizations. Further immunizations led to fast disappearance of the anti-idiotype antibody. These data suggest that anti-idiotype antibody production is a rather complicated process in which some suppressive mechanism is involved.
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