Effectiveness of two therapeutic antibiotic regimens in the treatment of serious post-operative infections
Askew, C.; Lomax, J.; Lawson, W.; Kingston, R.D.
British Journal of Clinical Practice 43(12): 438-442
1989
ISSN/ISBN: 0007-0947 PMID: 2692686 Document Number: 327768
A small prospective trial was conducted to evaluate the effectiveness and safety of a single antibiotic regimen, Augmentin, compared with a combination regimen of cefuroxime and metronidazole in the treatment of serious post-operative sepsis. Both regimens used were effective against Bacteroides and other anaerobes, with a similar satisfactory cure rate and no serious side effects. Intravenous Augmentin was easy to use and the change to oral therapy was significantly quicker than in the cefuroxime-metronidazole treatment arm. No significant resistance or serious adverse reaction was noted. The majority of patients had more than one site of infection, making selective antibiotic treatment difficult.