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Peripheral cholinolytic action--one of the effects of sidnofen

Samonina, G.E.; Mandriko, E.V.

Biulleten' Eksperimental'noi Biologii i Meditsiny 107(4): 449-451

1989

ISSN/ISBN: 0365-9615
PMID: 2720163
Document Number: 327470
Intravenous bolus injection of sydnophen (0.002-20 micrograms/kg) resulted in decrease or complete abolition of bradycardia induced by electrical stimulation of vagal peripheral end of anesthetized cats. The cholinolytic effects are dose-dependent. The small dose of sydnophen (0.002 micrograms/kg) which wasn't able to cause any alteration of EEG, heart rate and arterial pressure induced decrease of vagal bradycardia.

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