Study of the strontium response in isolated rat aorta
Barreda, A.; Anselmi, E.
Archives Internationales de Pharmacodynamie et de Therapie 299: 210-220
1989
ISSN/ISBN: 0003-9780 PMID: 2774765 Document Number: 327322
We have studied the effects of the cumulative application of Sr2+ in isolated rat aorta in a normal and in a Ca2+-free solution containing EDTA 1 mM. Sr2+ induced a concentration-dependent contraction which was reduced by verapamil (5 .times. 10-6 and 10-7 M) and lanthanum (1 and 2 mM). Sr2+ also induced a contraction in K+-depolarized medium. In aorta strips depleted of Ca2+ by several applications of noradrenaline (10-6 M), Sr2+ induced a dose-response contraction in a Ca2+-free solution. These findings suggest that the influx of external Ca2+ is only partly responsible for the Sr2+-induced contraction and that another intracellular mechanism is involved in the response.