Lyme disease: epidemiology, etiology, clinical spectrum, diagnosis, and treatment
Andiman, W.A.
Advances in Pediatric Infectious Diseases 1: 163-186
1986
ISSN/ISBN: 0884-9404 PMID: 3331275 Document Number: 3272
Lyme disease is a systemic, immune-mediated inflammatory disorder characterized by an unusual skin rash, erythema chronicum migrans, which may be followed by involvement of the central nervous system, heart, and joints. The early stages of the illness are almost always seen in summertime. The disease is caused by a spirochete, Borrelia burgdorferi, and is transmitted to humans by the bite of minute Ixodid ticks and, perhaps, other arthropods as well. In many patients the disease follows a chronic, relapsing course and, during the later stages, arthritis is the principal clinical manifestation. Endemic foci of disease are known to exist in at least 14 states in three regions of the country as well as in parts of Europe and Australia. All age groups are affected. The disease tends to occur in individuals living in or visiting rural, wooded neighborhoods or recreational areas.
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