Accessory and T cell defects in acquired and inherited hypogammaglobulinaemia
Rozynska, K.E.; Spickett, G.P.; Millrain, M.; Edwards, A.; Bryant, A.; Webster, A.D.; Farrant, J.
Clinical and Experimental Immunology 78(1): 1-6
1989
ISSN/ISBN: 0009-9104 PMID: 2530014 Document Number: 327191
Cellular defects in patients with common variable hypogammaglobulinaemia (CHV) and X-linked agammaglobulinaemia (XLA) have been studied in vitro, using a mitogen-driven system of immunoglobulin production. We have confirmed our previous finding of impaired low-density (dendritic) accessory cell function in CVH and now show that accessory cell function is normal in XLA. We demonstrate that macrophage accessory function is normal in CVH. T cell help for IgM production is also deficient in CVH, and T cell help in XLA is also abnormal for both IgG and IgM. Some XLA patients have excessive T suppressor activity. The contribution of these defects to the clinical states is discussed.