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Biological and haematological changes in experimental cryptosporidiosis

Aboul-Magd, L.A.; el-Ridi, A.M.; Michael, S.A.

Journal of the Egyptian Society of Parasitology 19(1): 49-56

1989

ISSN/ISBN: 1110-0583
PMID: 2708867
Document Number: 327125
In experimentally infected laboratory-bred white rats, Cryptosporidium infection rate was higher among immunosuppressed (75%) than immunocompetent ones (37.5%) with statistically insignificant difference. Cryptosporidiosis was found to be a fatal disease especially in immunosuppressed rats (50%). There was also marked flourishing of the infection as revealed by high intensity of infection in immunosuppressed than the immunocompetent rats (363 and 82.7 oocysts/pellet respectively). In spite of the severe disease, cyclophosphamide appeared to have no effect on the prepatent period. In both immunosuppressed and immunocompetent infected rats, there was a decrease in the total leucocytic count with marked lymphocytopaenia. This indicates decreased resistance to infection, thus higher oocyst counts in the pellets.

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